Mark Hallett, MD, Senior Investigator at National Institute of Neurological Disorders and Stroke (NINDS), Chief of the Medical Neurology Branch and Chief of Human Motor Control Section; Editor-in-Chief ofClinical Neurophysiology; Associate Editor ofBrain.

Werner Poewe, Chairman of the Department of Neurology at Medical University of Innsbruck; Editorial board member ofMovement Disorder,Journal of Neurology,Journal of Neural Transmission, andAktuelle Neurologie.

Preface ix

Contributors xi

Part I Parkinsons Disease and Parkinsonism

1 The Etiopathogenesis of Parkinsons Disease: Basic Mechanisms of Neurodegeneration 3
C. Warren Olanow and Kevin McNaught

2 Physiology of Parkinsons Disease 25
Shlomo Elias, Zvi Israel and Hagai Bergman

3 Pharmacology of Parkinsons Disease 37
Jonathan M. Brotchie

4 The Treatment of Early Parkinsons Disease 49
Olivier Rascol and Regina Katzenschlager

5 Treatment of Motor Complications in Advanced Parkinsons Disease 71
Susan H. Fox and Anthony E. Lang

6 Managing the Non-Motor Symptoms of Parkinsons Disease 91
Werner Poewe and Klaus Seppi

7 Surgery for Parkinsons Disease 121
Jens Volkmann

8 Future Cell- and Gene-Based Therapies for Parkinsons Disease 145
Tomas Björklund, Asuka Morizane, Deniz Kirik and Patrik Brundin

9 Parkinson-Plus Disorders 157
Martin Köllensperger and Gregor K. Wenning

Part II Tremor Disorders

10 Essential Tremor 179
Rodger J. Elble

11 Other Tremor Disorders 193
Günther Deuschl

Part III Dystonia, Cramps, and Spasms

12 Pathophysiology of Dystonia 205
Mark Hallett

13 General Management Approach to Dystonia 217
Cynthia L. Comella

14 Botulinum Toxin for Treatment of Dystonia 227
Dirk Dressler

15 Surgical Treatments of Dystonia 241
Christopher Kenney and Joseph Jankovic

16 Wilsons Disease 251
George J. Brewer

17 Cramps and Spasms 263
Christine D. Esper, Pratibha G. Aia, Leslie J. Cloud and Stewart A. Factor

18 Stiff Person Syndrome 283
Philip D. Thompson and Hans-Michael Meinck

Part IV Chorea, Tics and other Movement Disorders

19 Huntingtons Disease 295
Kevin M. Biglan and Ira Shoulson

20 Chorea 317
Francisco Cardoso

21 Treatment of Tics and Tourette Syndrome 331
Harvey S. Singer and Erika L.F. Hedderick

22 Therapeutics of Paroxysmal Dyskinesias 345
Shyamal H. Mehta and Kapil D. Sethi

23 Treatment of Miscellaneous Disorders 353
Marie Vidailhet, Emmanuel Roze and David Grabli

24 Myoclonus 363
Shu-Ching Hu, Steven J. Frucht and Hiroshi Shibasaki

Part V Drug-induced Movement Disorders

25 Neuroleptic-Induced Movement Disorders 373
S. Elizabeth Zauber and Christopher G. Goetz

26 Other Drug-Induced Dyskinesias 389
Oscar S. Gershanik

Part VI Ataxia and Disorders of Gait and Balance

27 Ataxia 407
Thomas Klockgether

28 Treatment of Gait and Balance Disorders 417
Bastiaan R. Bloem, Alexander C. Geurts, S. Hassin-Baer and Nir Giladi

Part VII Restless Legs Syndrome

29 The Restless Legs Syndrome 447
Richard P. Allen and Birgit H¤ogl

Part VIII Pediatric Movement Disorders

30 Pediatric Movement Disorders 471
Jonathan W. Mink

Part IX Psychogenic Movement Disorders

31 Psychogenic Movement Disorders 479
Elizabeth Peckham and Mark Hallett

Index 489