This is the second time that I have had the honor of opening an interna tional symposium dedicated to the functions of the hippocampus here in Pecs. It was a pleasure to greet the participants in the hope that their valuable contributions will make this meeting a tradition in this town. As one of the hosts of the symposium, I had the sorrowful duty to remind you of the absence of a dear colleague, Professor Graham God dard. His tragic and untimely death represents the irreparable loss of both a friend and an excellent researcher. This symposium is dedicated to his memory. If I compare the topics of the lectures of this symposium with those of the previous one, a striking difference becomes apparent. A dominating tendency of the previous symposium was to attempt to define hippocam pal function or to offer data relevant to supporting or rejecting existing theoretical positions. No such tendency is reflected in the titles of the present symposium, in which most of the contributions deal with hip pocampal phenomena at the most elementary level. Electrical, biochemi cal, biophysical, and pharmacological events at the synaptic, membrane, or intracellular level are analyzed without raising the question of what kind of integral functions these elementary phenomena are a part of.

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InhaltsangabeSynaptic Mechanisms of Long-Term Potentiation.- Long-Term Potentiation of Feed-Forward Inhibition in the Hippocampus: Extracellular Evidence.- Frequency Potentiation and Habituation in Hippocampal Area CA1.- Changes in Synaptic Transmission Evoked in the "In Vitro" Hippocampal Slice by a Brief Decrease of [Mg++]0: A Correlate for Long-Term Potentiation?.- Postsynaptic Mechanisms in the Potentiation of Synaptic Responses.- Postsynaptic Mechanisms May Regulate Synaptic Strength by Controlling Synapse Lifetimes.- Long-Term Potentiation of Inhibitory Responses in the Dentate Gyrus.- Quantal Analysis of Synaptic Plasticity in the Hippocampus.- Quantal Analysis of Long-Term Potentiation.- Plasticity-Related Synaptic Mechanisms in Hippocampus.- NMDA Receptor Control of Spontaneous Complex Spike Discharge in Hippocampal Pyramidal Cells.- Mecamylamine Blocks Responses to NMDA and a Component of Synaptic Transmission in Rat Hippocampal Slices.- LTP in the Recurrent Inhibitory Circuit of the Dentate Gyrus.- NMDA Receptors May Be Involved in Generation of Hippocampal Theta Rhythm.- Cytoplasmic Ca2+ Changes in Reference to Long-Term Potentiation in the Hippocampal Slice.- Electron Histochemical Localization of Calcium in CA1 of Hippocampal Slices Following High-Frequency Stimulation: Effects of Excitatory Amino Acid Antagonists.- Transmitter Mechanisms of Long-Term Potentiation.- Involvement of Serotonin in Hippocampal Plasticity.- Norepinephrine Enhances Long-Term Potentiation at Hippocampal Mossy Fiber Synapses.- Potentiation of Synaptic Transmission by Phorbol Esters Is Accompanied by a Reduction of Physiological Adenosine Action.- An APV-Resistant Non-associative Form of Long-Term Potentiation in the Rat Hippocampus.- GABA Transmission in the Hippocampus: Postsynaptic Regulation.- Glycine Allosterically Regulates an NMDA Receptor Coupled Ion Channel in Rat Hippocampal Membranes.- MK-801 Prevents the Induction of Long-Term Potentiation.- Long-Term Potentiation in Slices from Human Hippocampus.- Decrease of GABA During Long-Term Potentiation in the CA1 Region of Rat Hippocampal Slices: Immunohistochemical and Biochemical Analysis.- What Does Long-Term Potentiation Model?.- Synaptic Organization of Identified Neurons in the Hippocampus.- Hippocampal Sharp Waves: A Physiological Correlate of LTP?.- Characteristics of Associative Potentiation/Depression.- Primed Burst Potentiation: Lasting Synaptic Plasticity Invoked by Physiologically Patterned Stimulation.- Collective Behaviors of the Hippocampal Slice-Epileptic and Non-epileptic.- Are Nerve Growth Factors Involved in Long-Term Synaptic Potentiation in the Hippocampus and Spatial Memory?.- Molecular Mechanisms of Long-Term Potentiation.- Intracellular Injection of Protein Kinase C Causes Changes Similar to Long-Term Potentiation.- On the Mechanism of Increased Transmitter Release in LTP: Measurement of Calcium Concentration and Phosphatidylinositol Turnover in CA3 Synaptosomes.- Effects of Phorbol Esters on Membrane Currents and Synaptic Efficacy in the Hippocampus.- Gangliosides and Synaptic Plasticity in the Hippocampus.- Long-Term Synaptic Potentiation and Macromolecular Changes in Memory Formation.- Inhibitors of Protein Synthesis, but not mRNA Synthesis, Promote Decay of Long-Term Potentiation in Rat Dentate Gyrus.- A Multi-Phase Model of Synaptic Long-Term Potentiation in Hippocampal CA1 Neurones: Protein Kinase C Activation and Protein Synthesis Are Required for the Maintenance of the Trace.- Modulation of Spike Repolarization in Hippocampal Neurones by Tumor-Promoting Phorbol Esters.- Control of Excitability in Hippocampus.- Long-Term Potentiation in Relation to Kindling of the Rat Hippocampus.- The Role of M1 and M2 Receptors in Slow Muscarinic Excitation of Hippocampal Neurons.- Changes In Synaptic Function That Underly Epileptiform Activity In Hippocampal Pyramidal Cells.- Calcium and Long-Term Potentiation in the Rat Hippocampus In Vitro.- Memory-Affecting Drugs and Hippocampa