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Bone Morphogenetic Proteins: From Local to Systemic Therapeutics

Progress in Inflammation Research

Erschienen am 15.05.2008, 1. Auflage 2008
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Bibliografische Daten
ISBN/EAN: 9783764385514
Sprache: Englisch
Umfang: xi, 343 S., 79 s/w Illustr., 36 farbige Illustr.,
Format (T/L/B): 2.5 x 24 x 17.2 cm
Einband: gebundenes Buch

Beschreibung

InhaltsangabeDevelopment of a novel compression-resistant carrier for recombinant human bone morphogenetic protein-2 (rhBMP-2) and preliminary clinical results.- Use of recombinant human BMP-2 in orthopedic trauma.- The application of recombinant human bone morphogenetic protein on absorbable collagen sponge (rhBMP-2/ACS) to reconstruction of maxillofacial bone defects.- Clinical outcomes using rhBMP-2 in spinal fusion applications.- Bone morphogenetic protein signaling is fine-tuned on multiple levels.- Dissection of bone morphogenetic protein signaling using genome-engineering tools.- Alterations of BMP signaling pathway(s) in skeletal diseases.- Signaling cross-talk by bone morphogenetic proteins.- The role and mechanisms of bone morphogenetic protein 4 and 2 (BMP-4 and BMP-2) in postnatal skeletal development.- The role of bone morphogenetic protein 4 (BMP-4) in tooth development.- Bone morphogenetic protein antagonists and kidney.- Induction of cementogenesis and periodontal ligament regeneration by the bone morphogenetic proteins.- Control of bone mass by sclerostin: Inhibiting BMP- and WNT-induced bone formation.- Bone morphogenetic proteins in cartilage biology.- Systemic administration of bone morphogenetic proteins.

Produktsicherheitsverordnung

Hersteller:
Springer Basel AG in Springer Science + Business Media
juergen.hartmann@springer.com
Heidelberger Platz 3
DE 14197 Berlin

Inhalt

Development of a novel compression resistant carrier for recombinant human bone morphogenetic protein-2 (rhBMP-2) and preliminary clinical results.- Use of recombinant human BMP-2 in orthopedic trauma.- The application of rhBMP-2/ACS to reconstruction of maxillofacial bone defects.- Clinical outcomes using rhBMP-2 in spinal fusion applications.- BMP signaling is fine tuned on multiple levels.- Dissection of BMP signaling using genome engineering tools.- Alterations of BMP signaling pathway(s) in skeletal diseases.- Signaling crosstalk by bone morphogenetic proteins.- The role and mechanisms of bone morphogenetic protein 4 and 2 (BMP-4 and BMP-2) in postnatal skeletal development.- The role of bone morphogenetic protein 4 (BMP-4) in tooth development.- BMP antagonists and kidney.- Induction of cementogenesis and periodontal ligament regeneration by the bone morphogenetic proteins.- Control of bone mass by sclerostin: inhibiting BMP- and WNT-induced bone formation.- Bone morphogenetic proteins in cartilage biology.- Systemic administration of bone morphogenetic proteins